Umroh Akhir Ramadhan Lailatul Qodar

Berikut ini data dan fakta Agen Texas Poker Online Indonesia Terpercaya pertandingan Liga Champions antara Paris St

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Selama ribuan tahun, jahe sudah dikelompokkan sebagai penyedap masakan dan minuman, serta pengobatan.

Saco- - Selama ribuan tahun, jahe sudah dikelompokkan sebagai penyedap masakan dan minuman, serta pengobatan. Tanaman rimpang ini disukai karena efeknya yang menghangatkan tubuh. Salah satu khasiat lain dari jahe adalah membantu mengurangi gejala asma.

Para peneliti dari departemen anestesiologi Columbia University mengatakan, jika dikombinasikan dengan obat-obatan asma, jahe akan meningkatkan  efek rileksasi otot polos di sekitar saluran napas. Otot-otot ini menyempit saat serangan asma terjadi sehingga menyulitkan untuk bernapas.

Para peneliti menemukan ada tiga komponen spesifik dari jahe yang memiliki efek rileksasi sehingga baik jika dikombinasikan dengan obat asma. Ketua studi Elizabeth Townsend mengatakan, komponen jahe yang telah dimurnikan dapat bekerja secara sinergi dengan pengobatan asma dalam rileksasi otot saluran napas.

"Prevalensi asma meningkat beberapa tahun terakhir, namun dengan pengetahuan yang lebih baik tentang penyebabnya dan bagaimana penyakit ini berkembang, maka pengobatan baru yang lebih efektif dapat diciptakan," ujar Townsend.

Asma dikendalikan oleh otot yang mengetat di saluran udara yang disebut bronkokonstriksi. Maka selama ini asma diobati dengan betagonists yang berfungsi mengendurkan otot.

Untuk mengukur efek dari jahe, para peneliti mengambil sampel jaringan otot saluran napas dan memberikan paparan sebuah senyawa neurotransmiter yang disebut asetilkolin untuk membuat otot berkontraksi. Kemudian mereka memberikan tiga perlakukan berbeda pada otot polos yang berkontraksi tersebut.

Perlakukan pertama yaitu dengan memberikan isoproterenol, salah satu tipe bronkodilator, yang dicampur dengan komponen jahe 6-gingerol. Kedua, pengobatan ditambah komponen jahe 8-gingerol, dan yang tiga pengobatan ditambah komponen jahe 6-shogaol. Sedangkan ada juga kontrol yaitu dengan hanya memberikan pengobatan saja.

Hasilnya, ketiga perlakuan memberikan hasil yang lebih baik dibandingkan pengobatan saja. Khususnya, 6-shogaol merupakan komponen yang paling efektif dalam mengendurkan otot yang memperbaiki pengobatan asma.

Ketiga komponen bekerja dengan mempengaruhi enzim yang disebut dengan phosphodiesterase 4D (PDE4D). Penelitian sebelumnya menunjukkan enzim tersebut ditemukan di paru-paru, menghambat mekanisme rileksasi di saluran napas dan mengurangi inflamasi jaringan.

Para peneliti berharap studi ini dapat memberikan penjelasan yang lebih lanjut hingga ke tingkat seluler mengenai efektivitas komponen jahe untuk pengobatan saluran napas.

Sumber :Medical Daily/
Editor :Liwon Maulana(galipat)

Though Robin and Joan Rolfs owned two rare talking dolls manufactured by Thomas Edison’s phonograph company in 1890, they did not dare play the wax cylinder records tucked inside each one.

The Rolfses, longtime collectors of Edison phonographs, knew that if they turned the cranks on the dolls’ backs, the steel phonograph needle might damage or destroy the grooves of the hollow, ring-shaped cylinder. And so for years, the dolls sat side by side inside a display cabinet, bearers of a message from the dawn of sound recording that nobody could hear.

In 1890, Edison’s dolls were a flop; production lasted only six weeks. Children found them difficult to operate and more scary than cuddly. The recordings inside, which featured snippets of nursery rhymes, wore out quickly.

Yet sound historians say the cylinders were the first entertainment records ever made, and the young girls hired to recite the rhymes were the world’s first recording artists.

Year after year, the Rolfses asked experts if there might be a safe way to play the recordings. Then a government laboratory developed a method to play fragile records without touching them.


The technique relies on a microscope to create images of the grooves in exquisite detail. A computer approximates — with great accuracy — the sounds that would have been created by a needle moving through those grooves.

In 2014, the technology was made available for the first time outside the laboratory.

“The fear all along is that we don’t want to damage these records. We don’t want to put a stylus on them,” said Jerry Fabris, the curator of the Thomas Edison Historical Park in West Orange, N.J. “Now we have the technology to play them safely.”

Last month, the Historical Park posted online three never-before-heard Edison doll recordings, including the two from the Rolfses’ collection. “There are probably more out there, and we’re hoping people will now get them digitized,” Mr. Fabris said.

The technology, which is known as Irene (Image, Reconstruct, Erase Noise, Etc.), was developed by the particle physicist Carl Haber and the engineer Earl Cornell at Lawrence Berkeley. Irene extracts sound from cylinder and disk records. It can also reconstruct audio from recordings so badly damaged they were deemed unplayable.

“We are now hearing sounds from history that I did not expect to hear in my lifetime,” Mr. Fabris said.

The Rolfses said they were not sure what to expect in August when they carefully packed their two Edison doll cylinders, still attached to their motors, and drove from their home in Hortonville, Wis., to the National Document Conservation Center in Andover, Mass. The center had recently acquired Irene technology.


Cylinders carry sound in a spiral groove cut by a phonograph recording needle that vibrates up and down, creating a surface made of tiny hills and valleys. In the Irene set-up, a microscope perched above the shaft takes thousands of high-resolution images of small sections of the grooves.

Stitched together, the images provide a topographic map of the cylinder’s surface, charting changes in depth as small as one five-hundredth the thickness of a human hair. Pitch, volume and timbre are all encoded in the hills and valleys and the speed at which the record is played.

At the conservation center, the preservation specialist Mason Vander Lugt attached one of the cylinders to the end of a rotating shaft. Huddled around a computer screen, the Rolfses first saw the wiggly waveform generated by Irene. Then came the digital audio. The words were at first indistinct, but as Mr. Lugt filtered out more of the noise, the rhyme became clearer.

“That was the Eureka moment,” Mr. Rolfs said.

In 1890, a girl in Edison’s laboratory had recited:

There was a little girl,

And she had a little curl


Right in the middle of her forehead.

When she was good,

She was very, very good.

But when she was bad, she was horrid.

Recently, the conservation center turned up another surprise.

In 2010, the Woody Guthrie Foundation received 18 oversize phonograph disks from an anonymous donor. No one knew if any of the dirt-stained recordings featured Guthrie, but Tiffany Colannino, then the foundation’s archivist, had stored them unplayed until she heard about Irene.

Last fall, the center extracted audio from one of the records, labeled “Jam Session 9” and emailed the digital file to Ms. Colannino.

“I was just sitting in my dining room, and the next thing I know, I’m hearing Woody,” she said. In between solo performances of “Ladies Auxiliary,” “Jesus Christ,” and “Dead or Alive,” Guthrie tells jokes, offers some back story, and makes the audience laugh. “It is quintessential Guthrie,” Ms. Colannino said.

The Rolfses’ dolls are back in the display cabinet in Wisconsin. But with audio stored on several computers, they now have a permanent voice.

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